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NDB ID: RR0142    PDB ID: 2HHH 


Title:

CRYSTAL STRUCTURE OF KASUGAMYCIN BOUND TO THE 30S RIBOSOMAL SUBUNIT

Molecular Description:

30S RIBOSOMAL SUBUNIT

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 20 protein sequences

Primary Citation:

Schluenzen, F., Takemoto, C., Wilson, D.N., Kaminishi, T., Harms, J.M., Hanawa-Suetsugu, K., Szaflarski, W., Kawazoe, M., Shirouzo, M., Nierhaus, K.H., Yokoyama, S., Fucini, P.
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. 
Nat.Struct.Mol.Biol., 13, pp. 871 - 878, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 410.44   b = 410.44   c = 172.65 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.0 program. The R value is 0.268 for 205944 reflections in the resolution range 29.74 to 3.35 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)