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NDB ID: RR0158    PDB ID: 2OGM 


Title:

THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH THE PLEUROMUTILIN DERIVATIVE SB-571519

Molecular Description:

Ribosome
pleuromutilin derivative

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Davidovich, C., Bashan, A., Auerbach-Nevo, T., Yaggie, R.D., Gontarek, R.R., Yonath, A.
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. 
Proc.Natl.Acad.Sci.Usa, 104, pp. 4291 - 4296, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 170.396   b = 405.835   c = 703.8 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.1 program. The R value is 0.0 for 282308 reflections in the resolution range 29.93 to 3.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)