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NDB ID: RR0201    PDB ID: 3CF5 


Title:

THIOPEPTIDE ANTIBIOTIC THIOSTREPTON BOUND TO THE LARGE RIBOSOMAL SUBUNIT OF DEINOCOCCUS RADIODURANS

Molecular Description:

50S RIBOSOMAL PROTEIN L33
50S RIBOSOMAL PROTEIN L34
50S RIBOSOMAL PROTEIN L35
50S RIBOSOMAL PROTEIN L36
THIOSTREPTON
50S RIBOSOMAL PROTEIN L2
50S RIBOSOMAL PROTEIN L4
50S RIBOSOMAL PROTEIN L5
50S RIBOSOMAL PROTEIN L6
50S RIBOSOMAL PROTEIN L11
50S RIBOSOMAL PROTEIN L13
50S RIBOSOMAL PROTEIN L14
50S RIBOSOMAL PROTEIN L15
50S RIBOSOMAL PROTEIN L16
50S RIBOSOMAL PROTEIN L17
50S RIBOSOMAL PROTEIN L18
50S RIBOSOMAL PROTEIN L19
50S RIBOSOMAL PROTEIN L20
50S RIBOSOMAL PROTEIN L21
50S RIBOSOMAL PROTEIN L22
50S RIBOSOMAL PROTEIN L23
50S RIBOSOMAL PROTEIN L24
50S RIBOSOMAL PROTEIN L25
50S RIBOSOMAL PROTEIN L27
50S RIBOSOMAL PROTEIN L28
50S RIBOSOMAL PROTEIN L29
50S RIBOSOMAL PROTEIN L30
50S RIBOSOMAL PROTEIN L32

Structural Keywords:

SINGLE STRAND, LOOPS, HAIRPIN LOOPS

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 29 protein sequences

Primary Citation:

Harms, J.M., Wilson, D.N., Schluenzen, F., Connell, S.R., Stachelhaus, T., Zaborowska, Z., Spahn, C.M., Fucini, P.
Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin. 
Mol.Cell, 30, pp. 26 - , 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 169.9   b = 408.9   c = 694.5 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.1 program. The R value is 0.276 for 342617 reflections in the resolution range 30.0 to 3.3 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)