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NDB ID: RR0221    PDB ID: 3CXC 


Title:

THE STRUCTURE OF AN ENHANCED OXAZOLIDINONE INHIBITOR BOUND TO THE 50S RIBOSOMAL SUBUNIT OF H. MARISMORTUI

Molecular Description:

large ribosomal subunit 50S

Structural Keywords:

SINGLE STRAND, LOOPS, BULGES, FLIPPED-OUT,

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 28 protein sequences

Primary Citation:

Zhou, J., Bhattacharjee, A., Chen, S., Chen, Y., Duffy, E., Farmer, J., Goldberg, J., Hanselmann, R., Ippolito, J.A., Lou, R., Orbin, A., Oyelere, A., Salvino, J., Springer, D., Tran, J., Wang, D., Wu, Y., Johnson, G.
Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. 
Bioorg.Med.Chem.Lett., 18, pp. 6175 - 6178, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 213.66   b = 300.71   c = 575.37 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNX program. The R value is 0.0 for 333459 reflections in the resolution range 20.0 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)