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NDB ID: RR0222    PDB ID: 3CPW 


Title:

THE STRUCTURE OF THE ANTIBIOTIC LINEZOLID BOUND TO THE LARGE RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI

Molecular Description:

50S RIBOSOMAL SUBUNIT

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 28 protein sequences

Primary Citation:

Ippolito, J.A., Kanyo, Z.K., Wang, D., Franceschi, F.J., Moore, P.B., Steitz, T.A., Duffy, E.M.
Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit 
J.Med.Chem., 51, pp. 3353 - 3356, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 211.73   b = 298.58   c = 575.29 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNX program. The R value is 0.0 for 446872 reflections in the resolution range 40.0 to 2.7 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)