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NDB ID: RR0227    PDB ID: 3DLL 


Title:

THE OXAZOLIDINONE ANTIBIOTICS PERTURB THE RIBOSOMAL PEPTIDYL-TRANSFERASE CENTER AND EFFECT TRNA POSITIONING

Molecular Description:

50S ribosomal proteins/rRNA-23S ribosomal RNA/rRNA-5S ribosomal RNA
Linezolid Complex

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 28 protein sequences

Primary Citation:

Wilson, D.N., Schluenzen, F., Harms, J.M., Starosta, A.L., Connell, S.R., Fucini, P.
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning 
Proc.Natl.Acad.Sci.Usa, 105, pp. 13339 - 13344, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 169.7   b = 410.0   c = 695.0 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.1 program. The R value is 0.259 for 272947 reflections in the resolution range 29.98 to 3.5 Ångstroms with Fobs >  -3.0 sigma(Fobs) and with I >  0.0 sigma(I)