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NDB ID: RR0236    PDB ID: 3G4S 


Title:

CO-CRYSTAL STRUCTURE OF TIAMULIN BOUND TO THE LARGE RIBOSOMAL SUBUNIT

Molecular Description:

PROTEIN/RNA Complex

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 29 protein sequences

Primary Citation:

Gurel, G., Blaha, G., Moore, P.B., Steitz, T.A.
U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. 
J.Mol.Biol., 389, pp. 146 - 156, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 212.27   b = 299.84   c = 574.137 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.0 program. The R value is 0.0 for 250197 reflections in the resolution range 49.84 to 3.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)