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NDB ID: UR0032    PDB ID: 1Q29 


Title:

HAMMERHEAD RIBOZYME WITH 5'-5' G-G LINKAGE: CONFORMATIONAL CHANGE EXPERIMENT

Molecular Description:

5'-R(*GP*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3'/Ribozyme

Structural Keywords:

A DOUBLE HELIX, HAMMERHEAD, RNA HAMMERHEAD RIBOZYME, LOOP, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Dunham, C.M., Murray, J.B., Scott, W.G.
A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme. 
J.Mol.Biol., 332, pp. 327 - 336, 2003.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31 2 1

Cell Constants:

a = 66.689   b = 66.689   c = 140.528 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.1.24 program. The R value is 0.24559 for 6872 reflections in the resolution range 19.8 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)