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NDB ID: UR0055    PDB ID: 1YLS 


Title:

CRYSTAL STRUCTURE OF SELENIUM-MODIFIED DIELS-ALDER RIBOZYME COMPLEXED WITH THE PRODUCT OF THE REACTION BETWEEN N-PENTYLMALEIMIDE AND COVALENTLY ATTACHED 9-HYDROXYMETHYLANTHRACENE

Molecular Description:

ribozyme
(3AS
9AS)-2-PENTYL-4-HYDROXYMETHYL-3A
4
9
9A-TETRAHYDRO-4
9[1'
2']-BENZENO-1H-BENZ[F]ISOINDOLE-1
3(2H)-DIONE

Structural Keywords:

T SINGLE STRAND, LOOPS, HAIRPIN LOOP, HAMMERHEAD DNA-RNA RIBOZYME

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. 
Nat.Struct.Mol.Biol., 12, pp. 218 - 224, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 77.873   b = 43.269   c = 79.928 (Ångstroms)

α = 90.0   β = 106.19   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.1.9999 program. The R value is 0.21006 for 9979 reflections in the resolution range 20.0 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)